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NIHR studies due to report in 2020

EDNA: Early Detection of Neovascular Age-related macular degeneration

EFREEZE: A randomised controlled trial evaluating the clinical and cost-effectiveness of a policy of
freezing all embryos followed by thawed frozen embryo transfer, compared with a policy of
fresh embryo transfer in women undergoing in-vitro fertilization

MASTER: Male synthetic sling versus Artificial urinary Sphincter Trial for men with urodynamic stress
incontinence after prostate surgery: Evaluation by Randomised trial

The long-running ‘TISU’ trial, comparing different biomarker tests for assessing the risk of
extracorporeal shockwave lithotripsy versus acute kidney injury in critically ill patients who are
ureteroscopic removal as a treatment for ureteric considered for admission to critical care. The National
stones, reported to the funder in 2019. Publication Institute for Health and Care Excellence (NICE) are
of the economic evaluation findings is expected expected to publish guidance on this in 2020. AoT
in 2020. The year 2019 also saw publication of the researchers have also contributed to four further
economic evaluation findings from three trials that technology appraisals that commenced in 2019.
completed follow-up in recent years: the ‘CLASS’ Further, NICE has published Technology Appraisal
trial, comparing different treatment modalities guidance on the use of three new technologies in NHS
for patients with varicose veins; the ‘GOT-IT’ trial, England, for which researchers in the theme critiqued
assessing the effectiveness of glycerine triturate for the economic evidence and company submitted
retained placenta; and the HEALTH trial, comparing economic models.
sub-total hysterectomy to endometrial ablation for
Broader Measures of Value
the treatment of heavy menstrual bleeding. Work
also continued on several NIHR funded trials that are The theme’s ongoing interest in methods for
due to report to the funder in 2020. These include incorporating broader measures of value in economic
the ‘EDNA’, ‘EFREEZE’, and ‘MASTER’ trials. Long-term evaluation continued to evolve alongside our applied
follow-up of the previously reported ‘PROSPECT’ and project work in 2019. One PhD project being carried
‘VUE’ trials is also due in 2020. out alongside our work in the area of endometriosis is
exploring methods for measuring and incorporating
It has been a busy year with respect to the theme’s
variation in patient preferences into an economic
ongoing involvement in the University of Aberdeen’s
evaluation of alternative treatment approaches. This
Technology Assessment Reviews (TAR) contract
will help determine whether economic evaluation
(see Projects In-Progress and Completed 2019).
can be used to inform the delivery of more person-
Researchers from the theme were involved in a large
centred approaches to care that are being advocated
review and economic modelling exercise to evaluate
by health systems throughout the world.
the diagnostic accuracy and cost-effectiveness of

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